Chickenpox, for most of us, is remembered as a nasty childhood itch lasting a few days and it’s gone. For a minority it’s more serious, even life-threatening, but a vaccine is available to protect this population. 

Chickenpox is a common, preventable infection caused by the varicella-zoster (VZV) which, in the vast majority of cases, causes nothing more severe than an unpleasant itchy blistering rash. In certain vulnerable populations, however, it can cause more serious illness, even death. But this can be prevented by adoption of the vaccine against the varicella-zoster (VSV).

Signs and symptoms 

Some 90% of adults in temperate climates have had chickenpox by the time they reach adulthood. Once a person is infected, and has recovered from chickenpox, the virus lies dormant in a person’s body, only to wake up when they experience sickness or stress as adults and cause painful shingles. It is transmitted from person to person either by direct contact with skin blisters or by inhaling tiny viral particles suspended in the air. It is one of the most contagious diseases that is known to medicine. 

The chickenpox rash appears 10-21 days after exposure. The pox evolves from flat pink spots that blister with clear, then cloudy, fluid which then dry and crust.  The rash is invariably very itchy. Other symptoms include fever, loss of appetite, headache and malaise. 

The vast majority of people who get chickenpox will make a full recovery, but for certain vulnerable populations it can be a big problem. The groups at most risk include children and adults who need to take immunosuppressive medications for medical conditions such as arthritis or inflammatory bowel disease. If these patients contract the chickenpox virus, it can cause more severe disease that can damage the lungs, liver, or brain. Pregnant women are also at risk of severe disease, and the virus has the potential to damage the developing baby if infected in the womb. 

The vast majority of people who get chickenpox will make a full recovery, but for certain vulnerable populations it can be a big problem.

Vaccine in Ireland 

The VZV vaccine is licensed and marketed for use in Ireland. It is not yet part of the National Primary Immunisation Programme for all children in Ireland, but has been part of the vaccination schedule for all children in many countries such as Canada and the US. Parents can request it from their GP, however the cost for the vaccine and its administration is borne by the parent. The feasibility of Ireland adding the VZV vaccine to its national vaccine programme is undergoing evaluation.

The availability of a vaccine against the virus that causes chickenpox is great news for these vulnerable groups. Vaccinating all children early in life has the potential to protect the children themselves from both chickenpox and shingles. It also protects the children from severe disease if they subsequently need to take immunosuppressive medications. Furthermore, it prevents children from infecting vulnerable family members. The VZV vaccine is a live attenuated vaccine – or weakened form of the virus – and was first licensed for use in 1984. 

The usage data has proven VZV vaccines to be highly immunogenic, efficacious and safe. Chickenpox vaccination protects approximately 86-98% of children and 75% of adolescents and adults. 

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Irish community pharmacies are preparing to play an active role in the COVID booster and flu vaccination campaigns which are due to begin in the coming weeks.

Seasonal flu vaccination and COVID-19 booster shots are set to be made available as we approach the winter, providing dual protection against these two serious respiratory viruses. 

Dermot Twomey, President of the Irish Pharmacy Union (IPU) says, “Pharmacies have administered almost 300,000 COVID-19 vaccinations in recent months. We are ready to play our part in ensuring that our older and more vulnerable citizens are provided with this extra level of protection against COVID-19. 

Protecting the community 

Mr Twomey also urges everyone to register for a flu vaccine in the coming flu season, “We have all seen the damage a virus can do when it takes hold in our community. Flu remains a serious threat and we all have a duty to protect against it. 

“Pharmacists have been administering the flu vaccine for the last 10 years. Last flu season, over 300,000 people were vaccinated by their local pharmacist. Just as Irish people registered in their millions for COVID-19 vaccines, we hope to see a strong level of enthusiasm to protect against this perennial flu threat.

Pharmacies across Ireland have proven their immense value to their communities by their success in the vaccination programme.

Local vaccination services 

“As many people will have already experienced, pharmacies offer a highly convenient vaccination service. They are available in local communities, without the need to travel or join long queues. Pharmacies offer services from early morning to late evening and on weekends. They are consistently rated as the easiest to access component of our health system. This convenience will be an asset in these vaccination campaigns.”

Value of pharmacists in COVID-19 response

Mr Twomey commends the role played by pharmacies in the COVID-19 vaccine rollout since they began vaccinating last June, “Pharmacies across Ireland have proven their immense value to their communities by their success in the vaccination programme. Since the first vaccines were approved, we have been calling for them to be available in pharmacies and, when called upon by the HSE, the community pharmacy sector has delivered and will continue to do so.

“The gradual return to normality has come about thanks to the success of the COVID-19 vaccine rollout, helped by the participation of pharmacies across the country. Pharmacies are delighted to be playing a central role in vaccinating communities. We look forward to playing a central role in the rollout of both the COVID-19 booster vaccine and the influenza vaccine ahead of the winter flu season” concludes Mr Twomey. 

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The story of modern vaccines began in Europe when, in 1796, the English physician, Edward Jenner, carried out the world’s first controlled vaccination against smallpox. Later, in 1885, the French chemist, Louis Pasteur, would discover a vaccine for rabies. He is credited with laying the foundation for preventative medicine

COVID-19 has mainstreamed vaccines in public discourse. It joins about a dozen other diseases, including measles, meningitis and whooping cough, that we vaccinate against in Ireland.

Globally, vaccines prevent more than 20 life-threatening diseases. Vaccines have ridded the world of smallpox, driven polio to the brink of eradication, and virtually eliminated measles, diphtheria and rubella in many parts of the world. The World Health Organisation estimates that vaccines save up to three million lives annually. With the exception of clean drinking water, vaccination is among the best public health interventions ever.

A vaccine is a biological tool designed to prompt an immune response against an invading microorganism. Traditionally, vaccines are created using compromised forms of a virus. When the body is exposed to the vaccine, it is programmed to recognise the actual virus and fight it.

Immune response

Technology is disrupting traditional vaccine discovery routes. For COVID-19, two types of vaccines are in use – mRNA and viral vector. mRNA, used by Pfizer and Moderna, teaches the body to make a protein that will trigger an immune response without using a live virus. Viral vectors, used by Janssen and Astra Zeneca, deploy a harmless virus as a delivery system with instructions for the body’s cells. Both vaccine types prompt the body to make antibodies that fight COVID-19.

Like with treatments, safety is key for vaccines. Clinical trials must demonstrate that a vaccine is safe and effective before it is used in the community. Vaccines take time to develop – usually years, if not decades. On average, it takes between 12 and 36 months to manufacture one. Complex multivalent vaccines can have production lead times of more than 36 months. Quality controls can take up to 70% of the full manufacturing period.

Global collaboration

For COVID-19, breakthroughs happened in record time, super-charged by unprecedented global collaboration, already-laid research groundwork, and parallel production and regulatory processes that maintained safety and quality standards.

Every year, over 1.7 billion vaccines are produced at 27 manufacturing sites in 11 European countries, including Ireland. Europe has about a dozen vaccine research sites, leading to the discovery of next-generation vaccines for unmet medical needs and healthcare emergencies. More than 122,000 people work in Europe’s vaccines industry.

New vaccines are in development all the time. For example, industry and governments have long sought a vaccine for malaria, a disease that infects up to 600 million people annually and kills 400,000, mostly children. A new malaria vaccine has recently been found to be 77% effective against the disease.

Vaccines are a success story in global health. Let us continue to innovate for new vaccines so that we can stay a step ahead of disease.

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Brandon Viner

Site Director, Arklow

The world is beginning to recover from the pandemic with a global vaccine rollout. Ireland is in line to get 14 million doses of different vaccines in the course of 2021, with over 90% of people over 18 now fully vaccinated.

As the world begins to find a new normal, the fight against COVID-19 and indeed other diseases continues, with constant work on updating and developing vaccines. Not least through companies such as Merck, which has been on the frontline of the fight against the disease. The Life Science business of Merck is helping to respond with products and solutions at its two sites in Cork and Arklow that help scientists detect and characterise viruses and ultimately to develop vaccines and therapies.

Developing vital membrane

Martin McAuliffe is MD and Head of Cork Operations at Merck. “It is a centre of excellence for membranes, chromatography and analytical devices used by customers in the pharma and biopharma sectors for research and manufacturing applications,” McAuliffe says. “The Cork site produces millions of feet of all types of membrane on an annual basis. The lateral flow membrane is the key component in rapid diagnostic antigen tests, typically used in pregnancy tests and tests for infectious diseases like dengue fever, ebola and malaria. The membrane is also a key component in the rapid antigen tests for COVID-19.”

McAuliffe points out that with the onset of the pandemic, the facility’s main duty was to keep colleagues safe, but its second was to see how, following protocols on site, the company could continue to supply its essential products. “The customer demand for this type of membrane has significantly increased since the onset of COVID-19,” McAuliffe explains. “As a result, Merck’s Cork site has completed a €36 million expansion to double its output of lateral flow membrane annually. We have extensive experience in collaborating with our partners to support the production of rapid antigen tests, as a key supplier of lateral flow membrane.”

Merck has been based in Cork for over 30 years and has grown from a relatively small operation to now employing over 750 staff. As the site continues to expand, opportunities will arise in engineering, quality, process and technology operations areas in the next 12 months.

Increasing cholesterol production

Brandon Viner is Site Director in Arklow, which is primarily known for its production of cholesterol. “Merck Arklow is the primary centre for cGMP bulk manufacturing of commercial and late-stage APIs (active pharmaceutical ingredients) and advanced intermediates, high purity solvents, buffer solutions and excipients,” Viner says. “We have expertise in new process evaluation, process development and technology transfer and we currently have over 100 employees supporting the operation here.”

But it is cholesterol that is the key component and demand was exacerbated by the onset of the pandemic. “Our site is producing cholesterol, a key lipid which may be used as a component of mRNA therapeutics and vaccines,” says Viner. “Global demand for our product increased rapidly with the pandemic. We significantly scaled up our volumes over ten-fold in order to supply the global market. We are proud to be a collaborative partner in the development and supply of potentially life-saving therapies and vaccines.”

Working behind the scenes

Viner emphasises the importance of work behind the scenes and the commitment to providing vaccine development products.

“Our strategy starts with our people and we are outperforming through operational excellence,” Viner says. “We recognise the power of operational excellence when it is pervasive in the culture. Our lean manufacturing principles and support from our partners enabled us to successfully increase our cholesterol output by ten-fold.”

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Pharmacy doors remained open throughout the COVID-19 pandemic. Pharmacists quickly stepped up to assume a role in the National Vaccination Plan. Two community pharmacists share their perspectives.

Séamus Burke MPSI

Pharmacist, Haven Pharmacy Burke’s, 
Macroom, Co. Cork

Pharmacies step up 

Pharmacy teams have shown consistent dedication, determination and flexibility since the outbreak of COVID-19. Members of the Haven and totalhealth Pharmacy groups benefitted from the assistance of our support office in meeting the challenges of the pandemic, enabling us to focus on our patients’ needs, including COVID-19 vaccination.

Despite proving an effective resource in community vaccination programs, pharmacy involvement in the COVID-19 roll-out came later than expected. Throughout months of uncertainty about what role we would play, we prepared ourselves with additional vaccine training and pharmacy refits to facilitate vaccine clinics. Our support office assisted with procedures and policies, patient communication, and online registration.

Waiting lists can total thousands, with many patients registering with multiple locations.

Our vaccine service is well underway, though it has not been without challenge: delivery delays, vaccine shortages and ongoing guideline changes, some reported by the media before we are informed. Waiting lists can total thousands, with many patients registering with multiple locations, necessitating significant time confirming appointments to ensure every dose is used. For every vaccination, there is associated equipment, infection-control, counselling, monitoring, paperwork, EU Digital COVID Certificate generation; all while ensuring the day-to-day pharmacy operations continue.

Despite the challenges, it has been a privilege to help expedite the roll-out of COVID-19 vaccination.

Róisín Curley MPSI

Pharmacist, Curley’s totalhealth Pharmacy, Ballyhaunis, Co. Mayo

Untapped potential 

The unique position of community pharmacists offers many benefits to vaccination campaigns. By September 2021, over 250,000 COVID-19 vaccinations were administered in community pharmacies. As the healthcare provider who patients see the most, opportunities for education, reassurance, and support are obvious. People know and trust us; the familiar faces of the pharmacy team provided comfort to many vaccine-hesitant patients. Pharmacies also improve vaccine access, with diverse geographical reach and attractive opening hours, and an alternative to long queues and large crowds in vaccination centres.

By September 2021, over 250,000 COVID-19 vaccinations were administered in community pharmacies.

It did not take a global pandemic to invent pharmacy vaccination; we have carried out flu, shingles, and pneumonia vaccinations for many years. What the pandemic did advance was our reach. New regulations introduced included the ability to vaccinate off-site, email prescriptions and remote consultations.

The expansion of our capabilities cannot end here. Pharmacists could greatly increase access and uptake of many other vaccines, including childhood immunisations. With diverse clinical expertise, we also have the potential to free up our colleagues in general practice by supporting medication adherence, contraception provision, minor ailments treatment, and much more.

We are ready, willing, and more than able to participate in a more integrated healthcare system, prioritising patient-centred care, education, and preventative health.

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Over the past few decades, the global regulatory environment has become more stringent and demanding to consistently guarantee the quality, safety and efficacy of medicines and vaccines.

The increase in requirements by regulatory authorities has not been implemented equally across the world. Nowadays, we have a high heterogeneity in terms of dossier review, approval processes and timelines, with each country having specific data requirements and processes which often differ between countries. As such, it is virtually impossible for every country in the world to have access to medicines and vaccines at the same time.

Regulatory requirements under COVID-19

Unfortunately, while vaccines are widely recognised as the most important tool to exit the COVID-19 pandemic, regulatory requirements have not been harmonised and simplified across the world to expedite access.

It has highlighted some weaknesses in the system, more precisely in the regulatory management for manufacturing and controls. For instance, the processes to validate, approve and recognise new manufacturing facilities, an essential step in scaling up vaccine production, are still not agile enough.

There are multiple changes in process that can happen after a vaccine is first approved, such as new types of fridges used or tests performed. We can see dozens of changes each year, which you need to multiply by the number of countries where the vaccines are approved, resulting in thousands of variation dossiers. This will become even more significant for COVID-19 vaccines as data will change at a faster pace than for regular vaccines.

The processes to validate, approve and recognise new manufacturing facilities, an essential step in scaling up vaccine production, are still not agile enough.

Several countries perform testing on vaccine batches which is redundant and time-consuming, and not always using the same test method and applying the same specifications. Initial COVID-19 vaccine batches have limited expiration dates. Therefore, redundant local testing reduces the remaining shelf life for a vaccine, potentially resulting in discarding expired doses.

The emergence of variants has led to the need to react quickly by developing, manufacturing, and approving new vaccines against those variants, for whom most of the above challenges will also apply.

The way forward

There are four areas which provide solutions for the regulatory concerns, which are:

1. Science and risk based approaches.

2. Global regulatory harmonisation.

3. Use of reliance, work-sharing, and recognition processes.

4. Digitalisation.

These solutions are not new and, whilst this pandemic has witnessed some progress at authority level, a lot needs to be done. Ultimately, quick and widespread access to medicines and vaccines is most important.

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HPV vaccination saves lives. Get the facts and not the false stories. The HPV vaccine is safe and effective. HPV vaccination is cancer prevention.

What is HPV?

HPV (human papillomavirus) is a group of highly contagious and very common viruses.

There are more than 100 types of HPV, of which at least 14 can cause cancer. HPV types that can cause cancer are also known as ‘high risk HPV types’. (1)

Most people (at least 80%) will be infected with a form of HPV in their lifetime. HPV infection is most common in people in their late teens and early 20s. (2)

How is HPV transmitted?

HPV is transmitted through intimate sexual skin to skin contact during vaginal, oral or anal sexual intercourse or genital contact with an infected person. Anyone who is sexually active can contract it. Condom use reduces, but does not eliminate, the risk of transmission of HPV (2).

Most HPV infections do not need treatment because your body can clear the virus on its own. However, in some people, the HPV infection can develop into cancer or genital warts. (2)

Which cancer types are associated with or caused by HPV?

HPV causes 1 in 20 cancers worldwide. (2) A report in 2017 by the National Cancer Registry (NCRI) estimated that HPV infection cause up to 420 cancer cases (or up to 130 cancer deaths) per year in Ireland. Most of which are potentially preventable by HPV vaccination.

Virtually all cases of cervical cancer (>99%) are caused by sexually acquired infection with certain types of HPV. (2)

Two HPV types (HPV 16 and 18) cause 70% of cervical cancers and pre-cancerous cervical lesions.

Vaccines that protect against HPV 16 and 18 are recommended by WHO and have been approved for use in many countries. (1)

HPV can also cause cancer in boys and men. HPV infection can cause cancer of the anus, throat, penis and head and neck. By vaccinating both boys and girls – the better we can control the spread of HPV infection. (2)

HSE school’s vaccination programme

The HPV vaccine has been offered to girls in their first year of secondary school since 2010.

HPV vaccine has now also been offered to boys in their first year since September 2019.

The vaccines protect against types of HPV that cause nine out of 10 cervical cancers. Used with regular cervical screening later in life, the HPV vaccine is an effective way to prevent cervical cancer developing. (2). They can also protect boys from cancer types caused by high risk HPV and from genital warts.

The HPV vaccine is free for girls right up to sixth year, if not vaccinated in 1st year. It is currently only free for boysin their first year.

Two doses of the vaccine are required if under age 15, three doses are necessary for age 15 and older. (2)

Is the HPV vaccine safe?

The HPV vaccine has been studied internationally in over 1 million people since it was first introduced in 2006.

There is no scientific evidence in Ireland, or in any other country, that indicate that the HPV vaccine causes any long-term medical condition. (6)

Vaccines are strictly monitored and reviewed regularly by international bodies including:

• World Health Organization
• European Medicines Agency
• Centers for Disease Control and Prevention in the USA

A number of studies have been conducted that show there is no link between the HPV vaccine and chronic fatigue like conditions. A recent study in the US in June of this year also shows that there is no association between HPV vaccination and infertility in US females between 18–33 years old. (6,7)

Over 84 countries now have an HPV vaccine programme, with more than 20 of these countries giving the vaccine to both boys and girls (2)

Recent research carried out for more than 12 years to June of this year also indicate that there is no evidence of waning immunity, suggesting that there is currently no need for a booster dose of the HPV vaccine. (6)

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In the Irish Cancer Society, we are keenly aware of the devastation caused to people and families by HPV cancers.

Every day in Ireland, someone is diagnosed with a cancer caused by HPV, and more than two people die from this source of cancer every week.

Over nine in ten cervical cancer diagnoses are caused by HPV infections leading to around 90 deaths every year. They are also associated with other incredibly difficult diagnoses such as cancers of the throat, mouth, anus, cervix, vagina and penis.

The HPV vaccine in use at the moment is the most effective we have ever had, and has been proven time and again to be safe.

Elimination of HPV cancers

Through vaccination, we now have a unique opportunity to eliminate these cancers for future generations of our young people.

HPV vaccinations have come a long way in the last number of years. In Ireland, we are at a big advantage due to a number of important advances, including the introduction of HPV vaccinations for both boys and girls in the first year of secondary school.

The HPV vaccine in use at the moment is the most effective we have ever had, and has been proven time and again to be safe.

Uptake of the vaccine is expected to top 80% this year, according to the HSE, in what is a really encouraging sign as we seek to protect as many people as possible.

If we can make the right decisions now, both individually and as a community, then we in the Irish Cancer Society firmly believe that a future without HPV cancers will be achieved.

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As the demand for a global COVID-19 vaccine grows, increasing challenges emerge on misinformation around vaccinations.

This pandemic, the worst global health crisis in a century, has demonstrated the critical role vaccination has to play in keeping people safe, economies ticking over and threats to global health security at bay.

The fact is, we simply can’t end this crisis without COVID-19 vaccines. But as we race to develop them, this pandemic has also shown that there’s one thing that can spread faster than a virus during a pandemic – misinformation. This has led to what the World Health Organization (WHO) has dubbed an “infodemic” about COVID-19 and vaccines that now represents one of the biggest challenges to bringing this crisis to a swift end.

Vaccines need to be accessible to all

That can only happen if everyone has access to COVID-19 vaccines, regardless of where they live or of their ability to pay. Because until everyone is protected, this coronavirus will continue to spread, and the risk of resurgence will persist. So, not only do we have to develop COVID-19 vaccines that are both safe and effective, but we have to ensure that they are made available to everyone quickly, as soon as they are ready.

This pandemic has also shown that there’s one thing that can spread faster than a virus during a pandemic – misinformation.

That is why Gavi is working with partners to build a model for COVID-19 vaccine distribution which, for the first time in history, will ensure that every country gets access to COVID-19 vaccines at the same time, regardless of wealth.

Together with the WHO and the Coalition for Epidemic Preparedness Innovations (CEPI), this multilateral approach aims to avoid the mistakes of the past, such as what happened with swine flu in 2009 where only small number of countries cornered global supply of vaccines.

The most vulnerable can be most at risk of misinformation

But this effort, which has already received expressions of interest from more than 150 countries, and which will effectively be the single biggest vaccine deployment in history, now threatens to be undermined by a tsunami of fake news and misinformation about COVID-19 vaccines. This is particularly pernicious because those who are most vulnerable to the pandemic and its economic impacts, the poorest communities with the least level of support, are also where low levels of digital literacy make people more susceptible to misinformation and where limited access to reliable information can help it spread.

Improving digital literacy to reduce misinformation

We urgently need to build resilience to this false information and rebuild confidence in vaccines by raising levels of digital literacy, ensuring easy access to credible information and working with social media platforms, whose algorithms make it so easy for harmful rumours to propagate.

If trust in vaccines is undermined, not only will it hamper our efforts to end the misery and suffering this pandemic has brought, but it also threatens the huge strides we’ve made in recent decades in increasing equitable access to countless other life-saving vaccines. So, if we want to avoid outbreaks of other diseases as well, we need to ensure that everyone has access to vaccines and everyone sees the value of one world, protected.

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Vaccination is one of the most cost-effective health interventions available, saving millions of people worldwide from illness, disability and death each year.

I believe that vaccines are the best gift we can give our children and, even better, the health service gives them to us for free. If my son’s first birthday hadn’t been on a Sunday, he would have had his 12-month vaccines on his birthday. You never know when they will be exposed to infections, so it is really important to get vaccinated as soon as they are due.

In Ireland today, vaccines are offered to protect against 14 diseases: diphtheria, haemophilus influenzae (Hib) type b, hepatitis B, HPV infection, influenza, measles, meningococcal disease (types A, B, C, W & Y), mumps, pertussis (whooping cough), pneumococcal, polio, rotavirus, rubella and tetanus.

Vaccines protect the wider population

The World Health Organization (WHO) recommends a target uptake of 95% for childhood vaccines to protect everyone. We have reached the target uptake for some childhood vaccinations including diphtheria, tetanus, pertussis, polio and hepatitis B vaccines; however, we have not reached the target for measles, mumps, rubella, meningococcal, Hib and rotavirus vaccinations in Ireland.

When the majority of us are vaccinated we protect our children and ourselves.

When the majority of us are vaccinated we protect our children and ourselves. We also protect those who can’t be vaccinated, either because they’re too young, or because they have a weakened immune system.

There is a lot written on the internet about vaccines so sometimes it can be difficult to tell where to find accurate information. I would recommend looking at sources accredited by the WHO, with the Vaccine Safety Net (VSN) logo.

Communication with vaccine heroes

You can also talk to a health professional like your GP, pharmacist or practice nurse who can answer your questions.

We are asking everyone to be a vaccine hero, you can do this by

1. Getting vaccinated on time and completing your vaccination schedule
2. Sharing the facts about vaccine preventable diseases and the importance of vaccines
3. Look for information from credible sources like www.immunisation.ie and speak to a trusted health professional

Check your eligibility for the flu vaccine

It is important to remember that smallpox is the only vaccine-preventable disease that has been eradicated, so we need to keep vaccinating to prevent outbreaks of vaccine-preventable diseases.

As we approach flu season, I would encourage everyone eligible for the HSE flu vaccine programme to get vaccinated to protect themselves from flu. For the first time this year we are also offering the nasal flu vaccine to all children aged two to 12 years old. Both vaccine and administration are free for those eligible for the HSE programme.

www.immunisation.ie ||#KeepVaccinating

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